Alaric is an Infectious Diseases Fellow at Boston Children's Hospital and Harvard Medical School. He received his MD and PhD from Washington University in St. Louis, School of Medicine and did Pediatrics residency at Boston Children's Hospital on the accelerated research pathway. He completed his Computational and Systems Biology dissertation research on Microbial Ecology and antibiotic resistance genes in the Dantas Lab. After training, Alaric hopes to lead his own research group studying microbial ecology and antibiotic resistance.
Daily occupational exposure in swine farm alters human skin microbiota and antibiotic resistome
Chen DR, Cheng K, Wan L, Li G, Zhao DH, Yu Y, Liao XP, Liu YH, D’Souza AW**, Lian XL**, Sun J**
iMeta | PMID: 38868515 | 2024
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Acute and persistent effects of commonly-used antibiotics on the gut microbiome and resistome in healthy adults
Anthony WE, Wang B, Sukhum KV, D’Souza AW, Hink T, Cass C, Seiler S, Reske KA, Coon C, Dubberke ER, Burnham CA, Dantas G, Kwon JH
Cell Reports | PMID:35417701 | 2022
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Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family
Stogios PJ, Bordeleau E, Xu Z, Skarina T, Evdokimova E, Chou S, Diorio-Toth L, D'Souza AW, Patel S, Dantas G, Wright GD, Savchenko A
Communications Biology | PMID:35338238 | 2022
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supplemental |
preprint
Destination shapes antibiotic resistance gene acquisitions, abundance increases, and diversity changes in Dutch travelers.
D'Souza AW*, Boolchandani M*, Patel S, Galazzo G, Hattem J, Arcilla M, Melles D, Jong M, Schultsz C, Dantas G, Penders J
Genome Medicine | PMID:34092249 | 2021
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Manure microbial communities and resistance profiles reconfigure after transition to manure pits and differ from fertilized field soil
Sukhum K, Vargas R, D'Souza AW, Boolchandani M, Patel S, Kesaraju A, Walljasper G, Hedge H, Ye Z, Valenzuela R, Gunderson P, Bendixsen C, Dantas G, Shukla S
mBio | PMID:33975936 | 2021
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Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms
Sun J*, Liao XP*, D'Souza AW*, Boolchandani M*, Li SH*, Cheng K, Martinez JL, Li L, Feng YJ, Fang LX, Huang T, Xia J, Yu Y, Zhou YF, Sun YX, Deng XB, Zeng ZL, Jiang HX, Fang BH, Tang YZ, Lian XL, Zhang RM, Fang ZW, Yan QL, Dantas G, Liu YH
Nature Communications | PMID:32188862 | 2020
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supplemental
Genomic characterization of antibiotic resistant Escherichia coli isolated from domestic chickens in Pakistan
Rafique M*, Potter RF*, Ferreiro A, Wallace MA, Rahim A, Malik AA, Siddique N, Abbas MA, D'Souza AW, Burnham CD, Ali N, Dantas G
Frontiers in Microbiology | PMID:32010104 | 2019
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Cotrimoxazole prophylaxis increases resistance gene prevalence and α-diversity but decreases β-diversity in the gut microbiome of HIV-exposed, uninfected infants.
D'Souza AW*, Moodley-Govender E*, Berla B, Kelkar T, Wang B, Sun X, Daniels B, Coutsoudis A, Trehan I, Dantas G
Clinical Infectious Diseases | PMID:31832638 | 2019
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supplemental figures
Breakpoint beware: reliance on historical breakpoints for Enterobacteriaceae leads to discrepancies in interpretation of susceptibility testing for carbapenems and cephalosporins and gaps in detection of carbapenem-resistant organisms.
Yarbrough ML, Wallace MA, Potter RF, D'Souza AW, Dantas G, Burnham CD
European Journal of Clinical Microbiology & Infectious Diseases | PMID:31679102 | 2019
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Spatiotemporal dynamics of multidrug resistant bacteria on intensive care unit surfaces.
D'Souza AW*, Potter RF*, Wallace M, Shupe A, Patel S, Sun X, Gul D, Kwon JH, Andleeb S, Burnham CD, Dantas G
Nature Communications | PMID:31594927 | 2019
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supplemental code
Phenotypic and genotypic characterization of linezolid resistant Enterococcus faecium from the USA and Pakistan.
Wardenburg K*, Potter R*, D'Souza AW, Hussain T, Wallace M, Andleeb A, Burnham CA, Dantas G
Journal of Antimicrobial Chemotherapy | PMID:31504566 | 2019
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Sequencing-based methods and resources to study antimicrobial resistance.
Boolchandani M*, D'Souza AW*, Dantas G
Nature Reviews Genetics | PMID:30886350 | 2019
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Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes.
Baumann-Dudenhoeffer AM, D'Souza AW, Tarr PI, Warner BB, Dantas G
Nature Medicine | PMID:30374198 | 2018
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supplemental
Superficieibacter electus gen. nov., sp. nov., an Extended-Spectrum β-Lactamase Possessing Member of the Enterobacteriaceae Family, Isolated From Intensive Care Unit Surfaces.
Potter RF*, D'Souza AW*, Wallace MA, Shupe A, Patel S, Gul D, Kwon JH, Beatty W, Andleeb S, Burnham CD, Dantas G
Frontiers in Microbiology | PMID:30079059 | 2018
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supplemental
Draft Genome Sequence of the blaOXA-436- and blaNDM-1-Harboring Shewanella putrefaciens SA70 Isolate.
Potter RF*, D'Souza AW*, Wallace MA, Shupe A, Patel S, Gul D, Kwon JH, Andleeb S, Burnham CD, Dantas G
Genome Announcements | PMID:28729267 | 2017
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The rapid spread of carbapenem-resistant Enterobacteriaceae.
Potter RF*, D'Souza AW*, Dantas G
Drug Resistance Updates | PMID:27912842 | 2016
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Malignant cancer and invasive placentation: A case for positive pleiotropy between endometrial and malignancy phenotypes.
D'Souza AW and Wagner GP
Evolution, Medicine, and Public Health | PMID:25324490 | 2014
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Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family
Stogios PJ, Bordeleau E, Xu Z, Skarina T, Evdokimova E, Chou S, Diorio-Toth L, D'Souza AW, Patel S, Dantas G, Wright GD, Savchenko A
bioRxiv | DOI:10.1101/2021.09.10.459797 | 2021
PDF Published in Communications Biology
Microbiome and immune disruption accompany mouse death in a gnotobiotic mouse model of neonatal sepsis
Schwartz D, Wardenburg K, Shalon N, Ning J, Crofts T, D’Souza A, Robinson J, Henderson J, Warner B, Tarr P, Dantas G
Journal of the Pediatric Infectious Diseases Society | 2021
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The Gut Microbiome and Resistome of Healthy Volunteers are Restructured After Short Courses of Antibiotics
Anthony W, Sukhum K, Cass C, Reske K, Seiler S, Hink T, Coon C, D'Souza A, Wang B, Sun S, Dubberke E, Burnham C-A, Dantas G, Kwon JH
Infection Control & Hospital Epidemiology | 2020
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Longitudinal Analysis of ICU Surface Multidrug-resistant Organism Contamination in the US and Pakistan
Kwon JH, D'Souza A, Potter R, Wallace M, Shupe A, Patel S, Gul D, Andleeb S, Burnham CAD, Dantas G
Open Forum Infectious Diseases | 2017
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Autologous Fecal Microbiota Transplantation as a Strategy to Prevent Colonization With Multidrug-Resistant Organisms Following Antimicrobial Therapy
Bulow C, D'Souza A, Hink T, Wallace M, Reske K, Sun X, Kwon JH, Burnham CAD, Dantas G, Dubberke ER
Open Forum Infectious Diseases | 2015
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